Fludrocortisona [Inn-Spanish]
Brand names,
Fludrocortisona [Inn-Spanish]
Analogs
Fludrocortisona [Inn-Spanish]
Brand Names Mixture
Fludrocortisona [Inn-Spanish]
Chemical_Formula
C21H29FO5
Fludrocortisona [Inn-Spanish]
RX_link
http://www.rxlist.com/cgi/generic/fludro.htm
Fludrocortisona [Inn-Spanish]
fda sheet
Fludrocortisona [Inn-Spanish]
msds (material safety sheet)
Fludrocortisona [Inn-Spanish]
Synthesis Reference
No information avaliable
Fludrocortisona [Inn-Spanish]
Molecular Weight
380.45 g/mol
Fludrocortisona [Inn-Spanish]
Melting Point
No information avaliable
Fludrocortisona [Inn-Spanish]
H2O Solubility
140 mg/L
Fludrocortisona [Inn-Spanish]
State
Solid
Fludrocortisona [Inn-Spanish]
LogP
1.49
Fludrocortisona [Inn-Spanish]
Dosage Forms
Tablet
Fludrocortisona [Inn-Spanish]
Indication
For partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.
Fludrocortisona [Inn-Spanish]
Pharmacology
Fludrocortisone is a synthetic adrenocortical steroid possessing very potent mineralocorticoid properties and high glucocorticoid activity. It is indicated as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison’s disease and for the treatment of salt-losing adrenogenital syndrome. The physiologic action of fludrocortisone acetate is similar to that of hydrocortisone. However, the effects of fludrocortisone acetate, particularly on electrolyte balance, but also on carbohydrate metabolism, are considerably heightened and prolonged. Mineralocorticoids act on the distal tubules of the kidney to enhance the reabsorption of sodium ions from the tubular fluid into the plasma; they increase the urinary excretion of both potassium and hydrogen ions.
Fludrocortisona [Inn-Spanish]
Absorption
No information avaliable
Fludrocortisona [Inn-Spanish]
side effects and Toxicity
Effects of overexposure include irritation, cardiac edema, increased blood volume, hypertension, cardiac arrhythmias, enlargement of the heart, headaches, and weakness of the extremities.
Fludrocortisona [Inn-Spanish]
Patient Information
Fludrocortisona [Inn-Spanish]
Organisms Affected
Humans and other mammals